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The Hormone Solution Podcast with Karen Martel

Welcome to The Hormone Solution Podcast with Karen Martel – your personal invitation to a world of hormone health, sustainable weight loss, holistic well-being, and embracing life's stages with a big old dose of vitality and confidence.

May 25, 2024

Today, let’s talk about the correlation between hormone replacement therapy and weight gain, partially inspired by my own unexpected weight gain after starting testosterone therapy. We’ll examine the roles of estrogen, progesterone, and testosterone, examining how they can lead to both weight loss and gain, influenced by genetics and metabolism. While referencing clinical experience and research, we also discuss personalized HRT, the importance of liver health, and the impact of diet and xenoestrogens.

In this episode:

  • How hormone replacement therapy (HRT) can lead to unexpected weight gain, despite its weight loss associations.
  • Why progesterone's impact on thyroid function and metabolism can lead to weight changes during HRT.
  • How testosterone replacement in women may cause weight gain due to genetic predispositions.
  • Why estrogen replacement therapy sometimes results in initial weight gain in postmenopausal women.
  • How liver health and metabolism optimization can mitigate weight gain during HRT.
  • The influence of diet, alcohol consumption, and xenoestrogens on hormone balance.
  • How estrogen affects body composition through receptor sensitivity.
  • Why understanding the signs of hormone-related weight gain can aid in identifying hormonal imbalances.
  • How excessive progesterone can lead to weight gain, water retention, and mood changes.
  • Why testosterone therapy research is limited for women, but suggests it can aid in muscle maintenance.
  • How estrogen alone may improve lipid profiles and reduce centralized body fat in postmenopausal women.
  • Why adding testosterone to estrogen therapy can shift body composition toward increased lean mass.
  • How estradiol prevents visceral fat storage and impacts hunger regulation and insulin sensitivity.


Todays show is sponsored by: Eight Sleep
Go to and get $200 off plus free shipping on the Pod Cover by Eight Sleep. Use coupon code HORMONE.

Bioptimizers Sleep Breakthrough
Get 10% of your purchase with coupon code HORMONE.

Visit and use code KAREN15 for 10% off your first purchase of PushCatch® Liver Detox.

Interested in joining our NEW Peptide Weight Loss Program? Join today and get the details here.

Join our Women's Group Coaching Program OnTrack TODAY!

Karen Martel, Certified Hormone Specialist & Transformational Nutrition Coach and weight loss expert.


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